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The High Court hears arguments Wednesday regarding whether detainees held at Guantanamo Bay, Cuba, can challenge their imprisonment in federal court. The detainees claim the constitutionally guaranteed procedure called a writ of habeas corpus allows them a chance to rebut charges against them in front of a neutral judge.

Venezuelan President Hugo Chavez has suffered a startling defeat in a referendum that would have greatly enhanced his power, including ending presidential term limits. Voters rejected the referendum, 51 percent to 49 percent. Opponents said the country was hurtling toward dictatorship.

The day before the Thanksgiving holiday is among the busiest travel days of the year in the U.S. According to AAA, some 39 million Americans are due to travel at least 50 miles. Many will be in crowded airports where flights are bound to be either delayed or cancelled.

Deputy Director of National Intelligence Donald Kerr tells the House Permanent Select Committee on Intelligence that even though Iran froze weapons development in 2003, the country still retains key nuclear capabilities and also likely still wants the ability to make nuclear weapons.

A new National Intelligence Estimate on Iran concludes that the country's efforts to build a nuclear weapon had ceased back in 2003. The report is a stark contrast to the dire warnings issued from the Bush administration about a nuclear threat posed by Iran.

In Venezuela, millions of people turned out to vote Sunday in a controversial referendum that, if approved, would fundamentally alter the country's political and economic model and give President Hugo Chavez broad new powers. One of the provisions would allow Chavez to run for reelection indefinitely.

Transportation, gas, and electricity workers are demonstrating against President Sarkozy's plan to reform their retirement system.

President Bush is due to meet Israeli and Palestinian leaders at the White House. Afterward, he hopes they'll make progress talking with each other. This week might mark President Bush's deepest involvement in the conflict between Israelis and Palestinians.

The contentious issue of Iran dominates the Democratic presidential debate hosted by NPR and Iowa Public Radio. The candidates condemn President Bush's insistence that a new intelligence report showing Iran ceased its nuclear weapons program in 2003 made no difference.

Merck agrees to pay nearly $5 billion to settle lawsuits from consumers contending the painkiller Vioxx caused heart attacks and strokes. The safety problems of Vioxx and the withdrawal of Vioxx from the market was a watershed event in regulating prescription drugs in the U.S.